TYSND1 切割过氧化物酶体蛋白
中文名称
通路描述
蛋白质被导入过氧化物酶体后，一部分蛋白质被蛋白酶 TYSND1 切割（Okumoto et al. 2011）。基于人类 TYSND1 的突变（Okumoto et al. 2011）和模式植物拟南芥中的同源物（Schuhmann et al. 2008），TYSND1 似乎是一种含有保守组氨酸 - 天冬氨酸 - 丝氨酸三价的胰蛋白酶样丝氨酸蛋白酶。缺乏 Tysnd1 的小鼠中，一些过氧化物酶体的定位减少，脂肪酸的β-氧化和植物酸代谢降低（Mizuno et al. 2013）。缺乏 Tysnd1 的雄性小鼠由于精子缺乏顶体帽而不育。
英文描述
SARS-CoV-2 targets PDZ proteins in cell-cell junction PSD95/Dlg1/ZO-1 (PDZ) domains are protein-protein recognition sequences, consisting of 80â90 amino acids that bind to a PDZ-binding motif (PBM), usually located at the end of the carboxy-terminus of a target protein (Hung AY & Sheng M 2002; Gerek ZN et al. 2009; Munz M et al. 2012). Proteins containing PDZ domains are typically found in the cell cytoplasm or in association with the plasma membrane and play a role in a variety of cellular processes such as cell-cell junctions, cellular polarity, and signal transduction pathways. The multidomain structure of PDZ-containing proteins enables them to interact with multiple binding partners simultaneously, thereby assembling larger protein complexes (Harris BZ & Lim WA 2001). Viruses also encode PBM-containing proteins that bind to cellular PDZ proteins. Viral PBMs target cellular PDZ-containing proteins involved in tight junction formation, cell polarity establishment, and apoptosis (Javier RT & Rice AP 2011).
所含基因
5 个基因