FLT3 signaling through SRC family kinases

FLT3 signaling through SRC family kinases Several SRC family kinases (SFKs) have been shown to interact with active FLT3 to modulate downstream signaling. These include FYN, HCK, LCK and SYK (Heiss et al, 2006; Mitina et al, 2007; Chougule et al, 2016; Dosil et al, 1993; Marhall et al, 2017; Puissant et al, 2014; reviewed in Kazi and Ronnstrand, 2019a,b). The role of SFKs downstream of FLT3 is complex and not fully elucidated. Some family members appear to contribute positively to signaling, as assessed by elevated STAT5 signaling, while others may contribute to ubiquitin ligation and downregulation of the receptor through interaction with CBL (Chougule et al, 2016; Heiss et al, 2006; Marhall et al, 2017; reviewed in Kazi and Ronnstrand, 2019a,b).