ALK 融合和激活的点突变信号传导
中文名称
通路描述
ALK 在多种癌症中因扩增或过表达、融合事件或激活的点突变而激活，导致细胞内信号传导的持续激活。激活 ALK 后的主要下游通路包括 STAT3 和（较少）STAT5 信号传导，以及通过 MAP 激酶、PI3K/AKT 和 PLCγ级联反应（综述 Della Corte 等人 2018；Hallberg 和 Palmer 2013；Hallberg 和 Palmer 2016；Chiarle 等人 2008）。
英文描述
Signaling by ALK fusions and activated point mutants ALK is activated in a range of cancers as a result of amplification or overexpression, fusion event or activating point mutations, resulting, in general, in constitutive activation of intracellular signaling. The major pathways initiated downstream of activated ALK are STAT3 and, to a lesser extent, STAT5 signaling and signaling through the MAP kinase, PI3K/AKT and PLC gamma cascades (reviewed in Della Corte et al, 2018; Hallberg and Palmer, 2013; Hallberg and Palmer, 2016; Chiarle et al, 2008).
所含基因
26 个基因