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SARS-CoV-2 modulates host translation machinery

Reactome ID: R-HSA-9754678

中文名称

NODAL、BMP 和 WNT 对人类 2D 囊胚样细胞具有相似的影响

通路描述

NODAL、BMP 和 WNT 对人类 2D 囊胚样细胞具有相似的影响(Martyn et al. 2019)。中胚层和确定性的内胚层前体似乎已经在原基 streak 中分离和不同,因此如果存在双能中胚层前体,它们可能是暂时的(Probst et al. 2021)。中胚层是通过上皮 - 间质转化产生细胞通过原基 streak 的侵入形成的。内胚层不显示完整的上皮 - 间质转化,而是通过细胞塑性形成(在 Scheibner et al. 2021 的小鼠胚胎中推断,其中 E-cadherin 和 N-Cadherin 均表达)。然而,在小鼠胚胎中,内胚层前体仍然通过原基 streak 的前端区域侵入,与中胚层细胞一起迁移,并最终整合到内脏内胚层层以产生确定性的内胚层(Viotti et al. 2014)。
英文描述
SARS-CoV-2 modulates host translation machinery SARS-CoV-2 encodes several proteins that have been implicated in shutting off host expression (Banerjee AK et al. 2020; Finkel Y et al. 2021). This Reactome module describes SARS-CoV-2 nonstructural protein 1 (nsp1)-mediated shutdown of host protein translation by binding to the mRNA entrance channel on the 40S subunit (Banerjee AK et al. 2020), SARS-CoV-2 nsp16-mediated disruption of global mRNA splicing via binding to the 5′ splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome (Banerjee et al, 2020), and SARS-CoV-2 nsp8, nsp9-mediated suppression of protein integration into the cell membrane (Banerjee et al, 2020).

所含基因

48 个基因