NODAL、BMP 和 WNT 对人类 2D 囊胚样细胞具有相似的影响
中文名称
通路描述
NODAL、BMP 和 WNT 对人类 2D 囊胚样细胞具有相似的影响(Martyn et al. 2019)。中胚层和确定性的内胚层前体似乎已经在原基 streak 中分离和不同,因此如果存在双能中胚层前体,它们可能是暂时的(Probst et al. 2021)。中胚层是通过上皮 - 间质转化产生细胞通过原基 streak 的侵入形成的。内胚层不显示完整的上皮 - 间质转化,而是通过细胞塑性形成(在 Scheibner et al. 2021 的小鼠胚胎中推断,其中 E-cadherin 和 N-Cadherin 均表达)。然而,在小鼠胚胎中,内胚层前体仍然通过原基 streak 的前端区域侵入,与中胚层细胞一起迁移,并最终整合到内脏内胚层层以产生确定性的内胚层(Viotti et al. 2014)。
英文描述
SARS-CoV-2 modulates host translation machinery SARS-CoV-2 encodes several proteins that have been implicated in shutting off host expression (Banerjee AK et al. 2020; Finkel Y et al. 2021). This Reactome module describes SARS-CoV-2 nonstructural protein 1 (nsp1)-mediated shutdown of host protein translation by binding to the mRNA entrance channel on the 40S subunit (Banerjee AK et al. 2020), SARS-CoV-2 nsp16-mediated disruption of global mRNA splicing via binding to the 5â² splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome (Banerjee et al, 2020), and SARS-CoV-2 nsp8, nsp9-mediated suppression of protein integration into the cell membrane (Banerjee et al, 2020).
所含基因
48 个基因