线粒体 tRNA 加工
中文名称
通路描述
线粒体基因组每条环状链转录产生长多顺反子转录本，包括重链转录本和轻链转录本，随后被切割产生 tRNA、rRNA 和 mRNA。线粒体 RNase P 与核 RNase P 完全不同，具有不同的蛋白质亚基且不含 RNA 成分，在 tRNA 的 5' 端进行切割。RNase Z 是线粒体中 ELAC2 的异构体，在 tRNA 的 3' 端进行切割。未知核酸酶在线粒体 MT-CO3 的 5' 端、CO1 的 5' 端、CYB 的 5' 端和 ND6 的 3' 端进行额外切割。TRNT1（CCA 添加酶）随后在 tRNA 的 3' 端后转录后聚合添加通用接受序列 CCA。在酵母、植物和原生生物中，核编码的额外 tRNA 从细胞质导入线粒体（综述：Schneider 2011），但人类线粒体编码完整的 22 种 tRNA，尚未观察到 tRNA 导入。影响线粒体 tRNA 加工的突变会导致人类疾病，通常表现为能量需求组织（如脑和肌肉）中的异常（综述：Suzuki et al. 2011, Sarin and Leidel 2014）。
英文描述
N-Glycan antennae elongation N-glycans are further modified after the commitment to Complex or Hybrid N-glycans. The exact structure of the network of metabolic reactions involved is complex and not yet validated experimentally. Here we will show a generic reaction for each of the genes known to be involved in N-Glycosylation.
For a better annotation of the reactions and genes involved in the synthesis of Complex and Hybrid N-glycans we recommend the GlycoGene Database (Ito H. et al, 2010) (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotations of genes, and the Consortium for Functional Genomics (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotation of Glycan structures and reactions. Moreover, a computationally inferred prediction for the structure of this network is available through the software GlycoVis (Hossler P. et. al. 2006).
For a better annotation of the reactions and genes involved in the synthesis of Complex and Hybrid N-glycans we recommend the GlycoGene Database (Ito H. et al, 2010) (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotations of genes, and the Consortium for Functional Genomics (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotation of Glycan structures and reactions. Moreover, a computationally inferred prediction for the structure of this network is available through the software GlycoVis (Hossler P. et. al. 2006).
所含基因
15 个基因