严重急性呼吸综合征冠状病毒 2 型靶向宿主细胞内信号转导和调节通路
中文名称
通路描述
严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）编码几种蛋白质，这些蛋白质调节宿主细胞内信号转导和调节通路。其中包括膜蛋白 M、核蛋白 N 和 3a 蛋白，它们直接与 SARS-CoV-2 感染和细胞因子产生的宿主靶标结合。该 Reactome 模块描述了此类结合事件及其后果。首先，SARS-CoV-2 M 结合到 3-磷酸肌醇依赖性蛋白激酶 1（PDPK1）以抑制 PKB/Akt 激活（Ren Y 等，2021）。其次，SARS-CoV-1 N 结合到宿主 14-3-3 蛋白，该蛋白调节核质穿梭和其他功能（Tugaeva KV 等，2021）。第三，病毒 3a 与调节和支架蛋白 Caveolin-1（CAV1）的结合可能调节病毒摄取以及病毒结构蛋白的转运（基于 SARS-CoV-1 的同源蛋白推断）。
英文描述
SARS-CoV-2 targets host intracellular signalling and regulatory pathways Severe acute respiratory syndrome coronavirus type 2 (SARSâCoVâ2) encodes several proteins that modulate host intracellular signaling and regulatory pathways. Among them are membrane M, nucleocapsid N and 3a proteins that directly bind to host targets associated with SARSâCoVâ2 infection and cytokine production. This Reactome module describes several such binding events and their consequences. First, SARSâCoVâ2 M binds to 3âphosphoinositideâdependent protein kinase 1 (PDPK1) to inhibit PKB/Akt activation (Ren Y et al. 2021). Second, SARSâCoVâ1 N binds to the host 14-3-3 protein, which regulates nucleocytoplasmic shuttling and other functions of N (Tugaeva KV et al. 2021). Third, binding of viral 3a to the regulator and scaffolding protein caveolinâ1 (CAV1) may regulate virus uptake as well as the trafficking of viral structural proteins (inferred from the orthologous protein in SARS-CoV-1).
所含基因
13 个基因