MITF-M 依赖性基因调控涉及色素沉着
中文名称
通路描述
MITF 是黑色素细胞结构和组织形成的早期识别靶标。TYR、DCT 和 TYRP1 等酶通过 MITF 与启动子中的 M-box 结合来调控，最终将酪氨酸转化为黑素和棕黑素。此外，MITF 还调控黑色素小体结构成分（如 MLANA、SLC24A5、SILV 和 GPR143）的表达，尽管并非所有情况都直接证明了其结合和调控作用。RAB27A 和 MYO5A 编码基因也受 MITF 调控，负责黑色素小体的定位和运输。
英文描述
Transport of RCbl within the body The steps of transport of cobalamins (RCbl) from the enterocyte to the cells in which it will function as a cofactor, together with its reuptake in the renal tubule, are annotated here. While methylcobalamin is the predominant cobalamin in the blood (Chu et al. 1993), other cobalamins including cyanocobalamin and adenosylcobalamin are also present and the proteins involved in these processes accommodate all of them (Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010). This broad specificity is indicated by annotating R-cob(III)alamin (RCbl - CHEBI:140785) as the cargo in all of these processes.
所含基因
8 个基因