FLT3 ITD 和 TKD 突变介导的信号通路
中文名称
通路描述
FLT3 易受长度从 3 到 1236 碱基对的内切重复（ITD）影响，这些 ITD 通常位于胞内区，或较少见于酪氨酸激酶域（TKD），破坏受体的自抑制环，使其持续激活。FLT3 ITD 约占急性髓系白血病（AML）的 25%，是该癌症中最常见的突变。在较低频率下，FLT3 发生激活点突变（约占 AML 病例的 7%），这些突变倾向于聚集在 TKD 中，最常见的突变位点是激活环残基 D835 和门控残基 F691。FLT3 ITD 和 TKD 突变通过激活下游信号通路（如 MAP 激酶、PI3K/AKT 和 STAT5 级联）支持细胞转化。关于 ITD 和 TKD 突变激活的通路是否不同存在争议，有证据表明 STAT5 信号通路尤其特征性地与 FLT3 ITD 激活相关。
英文描述
Regulation of CDH11 function Like other classical cadherins, CDH11 associates with several catenin proteins through its intracellular domain, which is thought to play a role in the establishment and regulation of adherens junctions. These catenin proteins include CTNND1 (also known as p120 catenin or delta-catenin), CTNNB1 (beta-catenin), JUP (Junction Plakoglobin, also known as gamma-catenin), and CTNNA1 (alpha-catenin) (Straub et al. 2003; Kiener et al. 2006; Ortiz et al. 2015; Lee et al. 2018).
CDH11, through its C terminus, also forms a complex with angiomotin (AMOT) isoform p80 (AMOT-2), which is implicated in CDH11-mediated cell migration and tumor cell invasiveness (Levchenko et al. 2004; Jiang et al. 2006; Yi et al. 2011; Ortiz et al. 2015; Lee et al. 2018).
Through its extracellular region, CDH11 binds to the C terminal fragment of ANGPTL4 (Angiopoietin-like-4), commonly known as cANGPTL4, which is implicated in the regulation of wound healing. The variant isoform of CDH11 (CDH11v), an 85 kDa membrane-bound protein produced as a result of alternative splicing (Kawaguchi et al. 1999), can compete with the canonical CDH11 for cANGPTL4 binding (Teo et al. 2017).
CDH11, through its C terminus, also forms a complex with angiomotin (AMOT) isoform p80 (AMOT-2), which is implicated in CDH11-mediated cell migration and tumor cell invasiveness (Levchenko et al. 2004; Jiang et al. 2006; Yi et al. 2011; Ortiz et al. 2015; Lee et al. 2018).
Through its extracellular region, CDH11 binds to the C terminal fragment of ANGPTL4 (Angiopoietin-like-4), commonly known as cANGPTL4, which is implicated in the regulation of wound healing. The variant isoform of CDH11 (CDH11v), an 85 kDa membrane-bound protein produced as a result of alternative splicing (Kawaguchi et al. 1999), can compete with the canonical CDH11 for cANGPTL4 binding (Teo et al. 2017).
所含基因
9 个基因