金属硫蛋白结合金属
中文名称
通路描述
金属硫蛋白是一类高度保守、富含半胱氨酸的蛋白质，通过巯基键结合金属离子（近期综述见 Capdevila et al. 2012, Blindauer et al. 2014）。哺乳动物含有 4 种一般金属硫蛋白亚型（MT1、MT2、MT3、MT4）。MT1 亚型在灵长类动物中辐射进化，产生 8 到 9 个功能蛋白（具体取决于 MT1L 的分类）。每种哺乳动物金属硫蛋白结合 7 种二价金属离子，分为两个簇：α簇和β簇。尽管金属硫蛋白的具体功能尚未完全阐明，但它们似乎参与重金属解毒（综述见 Sharma et al. 2013）、储存和转运锌以及氧化还原生物化学。金属硫蛋白与许多其他细胞蛋白相互作用，大多数相互作用涉及中枢神经系统蛋白（综述见 Atrian and Capdevila 2013）。
英文描述
Regulation of CDH11 gene transcription The CDH11 gene consists of 14 exons, which encode two splice isoforms. Both splicing isoforms are expressed in the heart, brain, placenta, lung and bone, but not in the kidney, skeletal muscle, pancreas and liver (Okazaki et al. 1994; Kawaguchi et al. 1999). Several transcription factors have been shown to directly regulate CDH11 gene transcription, including HOXC8 (Lei et al. 2005; Lei et al. 2006; Li et al. 2014), ILF3 (Zhang et al. 2017), ZEB2 (Nam et al. 2012; Nam et al. 2014), HEYL (Liu et al. 2020), FOXF1 (Black et al. 2018), and BHLHE22 (Ross et al. 2012), and the transcription of CDH11 has also been shown to be influenced by a number of growth factors and hormones, such as FGF2 (Strutz et al. 2002; James et al. 2008), TNF (Wu et al. 2013), TGFB1 (Schneider et al. 2012; Schulte et al. 2013; Hahn et al. 2016; Cheng et al. 2018; Ruan et al. 2019; Doolin et al. 2021; Wilson et al. 2022), TGFB2 (Wecker et al. 2013; Theodossiou et al. 2019), GNRH1 (Peng et al. 2015), PTH (Yao et al. 2014), dexamethasone (Lecanda et al. 2000), progesterone (Chen et al. 1999). CDH11 can also affect TGFB1 signaling, thereby possibly creating a feedback loop (Passanha et al. 2022). Expression of mouse Cdh11 in mouse osteoblast-like cell line (MC3T3-E1) is not affected by osteogenic hormones triiodothyronine (T3) and 1,25-dihydroxyvitamin D3 at either mRNA or protein levels (Leugmayr et al. 2000).
所含基因
9 个基因