WNT 通路中 TCF 介导的信号转导
中文名称
通路描述
在人类细胞中已鉴定出 19 种 WNT 配体和 10 种 FZD 受体。这些配体与受体之间的相互作用在发育和组织特异性方面存在差异，并导致'经典'和'非经典'WNT 信号转导的激活。在经典 WNT 信号转导途径中，WNT 配体与 Frizzled (FZD) 和脂蛋白受体相关蛋白 (LRP) 受体的结合导致破坏复合物的失活、β-猫enin 的稳定性和核转位，进而激活 T 细胞因子/淋巴增强因子 (TCF/LEF) 介导的转录。经典 WNT 信号转导引起的转录激活控制细胞命运、增殖和干细胞自我更新等过程，并有助于肿瘤发生（参见 MacDonald et al, 2009; Saito-Diaz et al, 2013; Kim et al, 2013）。
英文描述
Positive Regulation of CDH1 Gene Transcription Numerous transcription factors have been identified as direct positive regulators of transcription of CDH1 gene (also known as E-cadherin, epithelial cadherin, Cadherin-1, CADH1, or uvomorulin). Only those transcription factors reported to directly stimulate CDH1 gene transcription in at least two studies have been annotated in this pathway. These include ARID1A (Yan et al. 2014; Baldi et al. 2022), FOXA2 (Zhang et al. 2015; Bow et al. 2020; Liu et al. 2021), FOXJ2 (Martin de Lara et al. 2008; Zhang et al. 2018), KLF4 (Yori et al. 2010; Bjerke et al. 2011; Koopmansch et al. 2013; Lee et al. 2014; Lin et al. 2018), KLF9 (Zhong et al. 2018; Bai et al. 2021), RB1 (Batsche et al. 1998; Decary et al. 2002; Arima et al. 2008), SP1 (Mauro et al. 2007; Jin and Datta 2014; Zhang et al. 2022), and TFAP2A (Faraldo et al. 1997; Batsche et al. 1998; Decary et al. 2002; Schwartz et al. 2007; Arima et al. 2008).Transcription factors implicated in direct upregulation of CDH1 gene transcription by a single study are not shown in the pathway diagram. These include CREB1 (Mauro et al. 2007), GATA3 (Yan et al. 2010), GRHL2 (Werth et al. 2010), GRHL3 (Alotaibi et al. 2015), MITF (Mansky et al. 2002), MSX2 (Lin et al. 2018), NACC1 (Faiola et al. 2017), PDX1 (Marty Santos et al. 2016), RUNX2 (Li et al. 2018), and TFAP2C (Wang et al. 2020).
所含基因
11 个基因