SLITs和ROBOs表达调控
中文名称
通路描述
SLIT和ROBO蛋白的表达受转录、翻译和蛋白定位及稳定性水平调控。LHX2、LHX3、LHX4、LHX9和ISL1 LIM-homeodomain转录因子已涉及细胞类型依赖性对ROBO1、ROBO2、ROBO3和SLIT2的转录调控（Wilson et al. 2008, Marcos-Mondejar et al. 2012, Kim et al. 2016）。HOXA2转录因子参与ROBO2的转录调控（Geisen et al. 2008）。Xenopus中SLIT1的转录在FGF信号刺激下发生，可能也涉及HOXA2转录因子，但机制尚未阐明（Atkinson-Leadbeater et al. 2010）。PAX6和NKX2.2转录因子也参与SLIT1转录调控（Genethliou et al. 2009）。MSI1 RNA结合蛋白结合ROBO3 mRNA并促进其翻译，从而增加ROBO3蛋白水平（Kuwako et al. 2010）。ZSWIM8 E3泛素连接酶促进ROBO3降解（Wang et al. 2013）。ROBO1的半衰期增加是通过ROBO1被泛素蛋白酶USP33去泛素化实现的（Yuasa-Kawada et al. 2009, Huang et al. 2015）。SLIT2与DAG1（粘蛋白）的相互作用对于SLIT2在板层区的正确定位至关重要（Wright et al. 2012）。SLIT1与IV型胶原蛋白COL4A5的相互作用对于SLIT1向光学节段基底膜的正确定位至关重要（Xiao et al. 2011）。
英文描述
Regulation of NPAS4 mRNA translation The 3'UTR of NPAS4 mRNA is highly conserved between mouse, rat and human (>95% identity across ~700 bp of the 3'UTR sequence). Of the three putative microRNAs, miR-224, miR-203 and miR-132/212, that were predicted to target the 3'UTR of NPAS4 mRNA by multiple computational algorithms, miR-224 and miR-203 were able to significantly downregulate expression of the NPAS4 3âUTR reporter construct (Bersten et al. 2014). Downregulation of Npas4 expression by miR-224 was also shown in mouse (Choy et al. 2017). Npas4 was also reported as a target gene of miR-1 (Forget et al. 2021), miR-142 (Ji et al. 2019) and miR-744 (Choy et al. 2017). Only microRNAs that were reported to target Npas4 mRNA by at least two studies are shown in the diagram. The circulatory RNA circ_0003420 was also reported to target NPAS4 mRNA and contribute to its degradation (Xiong et al. 2021).
所含基因
9 个基因