MAP2K 突变介导的信号通路
中文名称
通路描述
MAP2K1 和 MAP2K2 基因（编码 MEK1 和 MEK2）中的激活突变在多种癌症以及诺安综合征、心脏面部皮肤综合征和其他 RAS 疾病（综述：Samatar 和 Poulikakos, 2014; Bezniakow 等，2014; Rauen, 2013）中被发现，频率较低。
英文描述
NFE2L2 regulating anti-oxidant/detoxification enzymes Subpathway representing cytoprotective genes regulated by NFE2L2 (NRF2). NFE2L2 is well-studied for its role in oxidative stress where it gets activated by ROS and then induces a plethora of gene expression regulation the oxidative damage. It induces genes/enzymes that regulate the phase 2 detoxification system (eg. GSTs and Glutathione system), ROS scavenging (SODs,PRDX1 ) and cytoprotection (HO1) by regulating inflammation and tissue damage (Tonelli et al, 2018; Shaw et al, 2020)
所含基因
21 个基因