LRR FLII-interacting protein 1 (LRRFIP1) 激活 I 型干扰素产生
中文名称
通路描述
LRRFIP1 可结合外源双链 RNA 和双链 DNA。研究表明，LRRFIP1 通过调节β-catenin 活性介导了小鼠原代巨噬细胞中链球菌和乙型脑炎病毒诱导的 IFN-β产生。β-catenin 可能作为 IRF3 的转录共激活因子，启动 Ifnb1 转录。
英文描述
NFE2L2 regulating ER-stress associated genes Subpathway representing ER-stress-associated genes regulated by NFE2L2 (NRF2). Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of adaptive genes that allow cells to endure periods of stress, such as hypoxia or amino acid limitation. However, under persistent stress conditions, ATF4 promotes the induction of apoptosis (Wortel et al, 2017). ATF4 is also known to regulate serine and glycine biosynthesis in NSCLC (Denicola et al, 2016)
所含基因
4 个基因