母源 mRNA 的衰变：由母源储存因子降解
中文名称
通路描述
母源转录本在卵母细胞形成期间从母源基因组转录并积累在卵母细胞中。在受精后的未受精卵母细胞发育后期和受精后，其中一部分母源转录本被降解。母源转录本的衰变（M-decay，reviewed in Jian and Fan 2022）是指由母源提供的因子（如 ZFP36L2，基于 Chousal et al. 2018, Sha et al. 2018 的小鼠同源物推断；BTG4，基于 Liu et al. 2016, Yu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020 的小鼠同源物推断；AGO2，基于 Zhang et al. 2020 的小鼠同源物推断）降解母源转录本。ZFP36L2 在受精前起作用，BTG4 在受精后起作用，它们招募 CCR4-NOT 去腺苷酸化复合物到 mRNA 上以启动降解。AGO2 被内源性小干扰 RNA（endo-siRNAs）激活，这些 siRNAs 源自双链 RNA，这些 dsRNA 源自特定位点。AGO2:endo-siRNA 复合物结合并水解互补的母源 mRNA。在人类和小鼠受精卵中观察到类似的 mRNA 衰变模式（Sha et al. 2020）。
英文描述
M-decay: degradation of maternal mRNAs by maternally stored factors Maternal transcripts are transcribed from the maternal genome and accumulate in the oocyte during oogenesis. A subset of these maternal transcripts is degraded during later development of the unfertilized oocyte and after fertilization of the oocyte. Maternal decay of maternal transcripts (M-decay, reviewed in Jian and Fan 2022) refers to the degradation of maternal transcripts by maternally provided factors such as ZFP36L2 (inferred from the mouse homolog in Chousal et al. 2018, Sha et al. 2018), BTG4 (inferred from the mouse homolog in Liu et al. 2016, Yu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020), and AGO2 (inferred from the mouse homolog in Zhang et al. 2020). ZFP36L2 acting before fertilization and BTG4 acting after fertilization recruit the CCR4-NOT deadenylation complex to the mRNA to initiate degradation. AGO2 is primed with endogenous small interfering RNAs (endosiRNAs) produced from double-stranded RNAs that originate from specific loci. The resulting AGO2:endosiRNA complexes bind and hydrolyze complementary maternal mRNAs. Similar patterns of mRNA decay are observed in human and mouse zygotes (Sha et al. 2020).
所含基因
25 个基因