Z 衰变：由受精卵表达因子降解母源 mRNA
中文名称
通路描述
母源转录本在卵母细胞形成期间积累。母源转录本的子集在受精后的未受精卵母细胞发育后期和受精后被降解。Z 衰变（Z-decay）是指受精后由受精卵基因组表达因子降解母源转录本。在受精卵中，YAP1:TEAD4 复合物激活 TUT4 和 TUT7 的表达，然后它们对特定部分去腺苷酸化母源转录本的 3'端进行尿苷酰化（基于小鼠受精卵在 Sha et al. 2020 中的推断）。末端尿苷酸残基招募 PABPN1，进而招募 3'-5' 核糖核酸酶 DIS3L2 降解 mRNA（基于 Zhao et al. 2022 中的小鼠同源物推断）。TUT4、TUT7 或 PABPN1 的缺失会导致 mRNA 丰度改变（基于小鼠受精卵在 Morgan et al. 2017, Sha et al. 2020, Zhao et al. 2022 中的推断）和不育症（Morgan et al. 2017, Zhao et al. 2022）。BTG4 在卵母细胞中表达并在受精卵中存在，可能通过招募 CCR4-NOT 复合物在尿苷化之前去腺苷化 mRNA（基于 Sha et al. 2020 中的小鼠受精卵推断）。在人类和小鼠受精卵中观察到类似的表达模式和 mRNA 衰变模式（Sha et al. 2020）。
英文描述
Z-decay: degradation of maternal mRNAs by zygotically expressed factors Maternal transcripts accumulate in the oocyte during oogenesis. Subsets of maternal transcripts are degraded during later development of the unfertilized oocyte and after fertilization of the oocyte. Zygotic decay (Z-decay) refers to the degradation of maternal transcripts by factors expressed by the zygotic genome after fertilization. In the zygote the YAP1:TEAD4 complex activates expression of TUT4 and TUT7 which then uridylate the 3' ends of specific, partially deadenylated maternal transcripts (inferred from mouse zygotes in Sha et al. 2020). The terminal uridylate residues recruit PABPN1 which recruits the 3'-5' ribonuclease DIS3L2 to degrade the mRNA (inferred from mouse homologs in Zhao et al. 2022). Absence of TUT4, TUT7, or PABPN1 results in altered mRNA abundances (inferred from mouse zygotes in Morgan et al. 2017, Sha et al. 2020, Zhao et al. 2022) and infertility (Morgan et al. 2017, Zhao et al. 2022). BTG4 expressed in oocytes and present in zygotes also plays a role in Z-decay possibly by recruiting the CCR4-NOT complex to deadenylate mRNAs prior to uridylation (inferred from mouse zygotes in Sha et al. 2020). Similar patterns of expression and mRNA decay are observed in human and mouse zygotes (Sha et al. 2020).
所含基因
12 个基因