MITF 对 DNA 复制、损伤修复和衰老相关基因的调控
中文名称
通路描述
MITF 靶基因涉及 DNA 复制、损伤修复和染色体维持与稳定性。通过 siRNA 耗尽 MITF 的细胞会因积累 DNA 损伤而发生衰老。相反，通过 ATF4 过表达耗尽 MITF 的细胞会发生可逆的细胞周期阻滞，但不发生衰老，这表明 ATF4 和翻译重编程可能阻断了衰老通路。
英文描述
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence MITF target genes are involved in DNA replication, damage repair and chromosome maintenance and stability (Strub et al, 2011; Giuliano et al, 2010; Seoane et al, 2019; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). Cells depleted of MITF through siRNA can undergo senescence as a result of accumulating DNA damage. In contrast, cells that are depleted of MITF by overexpression of ATF4 undergo reversible cell cycle arrest but do not undergo senescence, suggesting that ATF4 and translational reprogramming may block the senescence pathway (Giuliano et al, 2010; Falletta et al, 2017; reviewed in Goding and Arnheiter, 2019).
所含基因
6 个基因