蛋白 M 成熟
中文名称
通路描述
该 COVID-19 通路是通过结合 SARS-CoV-1 数据的计算推断和手动校订创建的，具体描述见整体 SARS-CoV-2 感染通路摘要。蛋白 M 是 N-糖基化的，在 Golgi 复合体中积累，并招募 Spike 蛋白至病毒组装和出芽位点（ERGIC），Voss 等，2006；Voss 等，2009。
英文描述
Maturation of hRSV A proteins Human respiratory syncytial virus contains 10 genes which are translated into 11 proteins, of which 2 have translation isoforms due to use of alternative translation initiation codons. These proteins function in viral replication and host interaction. Fusion protein F, glycoprotein G, and both variants of small hydrophobic protein, SH and SHt, get glycosylated and F, G, and SH later migrate to the plasma membrane where virion assembly takes place. Matrix protein M first translocates to the nucleus and back to cytosol before serving as a scaffold at the assembly site. M2-1 is also found in the nucleus. Phosphorylations, partially transient, appear to be necessary for oligomerization and function of the SH, N, P, M, and M2-1 proteins (Gan & Torres, 2011; McLellan et al, 2013; Muniyandi et al, 2018; Anderson et al, 2021).
所含基因
25 个基因