多巴胺受体
中文名称
通路描述
多巴胺受体在学习、动机、精细运动控制及神经内分泌信号调节中发挥关键作用。多巴胺受体信号异常可能导致帕金森病和精神分裂症等神经精神疾病。多巴胺受体在中枢神经系统（CNS）中显著存在，多巴胺是该受体的主要内源性配体。人类中存在五种不同类型的大脑多巴胺受体，即 D1-D5。它们分为两类：D1 样家族（D1 和 D5），通过 G 蛋白α亚基αs 耦合，具有兴奋性；D2 样家族（D2、D3 和 D4），通过 G 蛋白α亚基αi 耦合，具有抑制性。
英文描述
Evasion by RSV of host interferon responses Infection with human respiratory syncytial virus (hRSV) is typically associated with low to undetectable levels of type I interferons (IFNs). Several hRSV proteins interact with host innate immune system factors that support the type I interferon response. Nonstructural proteins NS1 and NS2 localize to mitochondria and nucleus where they bind MAVS, DDX58, TRIM25, IRF3, and CREBBP, affecting DDX58/IFIH1-mediated interferon induction (reviewed by Thornhill & Verhoeven, 2020). Additionally, hRSV nucleoprotein interacts with MDA5 downregulating the interferon response and with PKR (EIF2AK2) blocking the innate immune system signal for shutting down protein translation. Further interactions of the M, SH, and G proteins are reviewed by van Royen et al, 2022.
所含基因
35 个基因