TCA 酶成熟和 TCA 循环的调控
中文名称
通路描述
(Citrate-synthase)-赖氨酸 - 甲基转移酶 (CSKMT, METTL12) 将三个甲基从 S-腺苷甲硫氨酸 (SAM) 转移到 citrate synthase (CS) 的赖氨酸 -395。CSKMT 的表达在许多正常器官组织中含量低或缺失，但在大多数测试的细胞系中，三甲基化形式占主导地位。该修饰在进化上保守，关于修饰 CS 活性的报告存在矛盾，而 CS/ACO2 代谢体对整个的影响尚未研究。Oxalocetate 抑制甲基转移酶活性 (Malecki et al., 2017; Rhein et al., 2017; 综述 Qi et al., 2023)。
英文描述
Maturation of TCA enzymes and regulation of TCA cycle (Citrate-synthase)-lysyl-methyltransferase (CSKMT, METTL12) transfers three methyl groups from S-adenosylmethionine (SAM) to lysine-395 of citrate synthase (CS). The expression of CSKMT is low or absent in many normal organ tissues, but the trimethylated form is predominant in most cell lines tested. The modification is evolutionarily conserved, with contradicting reports on the activity of modified CS, while the effect on the whole CS/ACO2 metabolon was not investigated. Oxalocetate inhibits methyltransferase activity (Malecki et al., 2017; Rhein et al., 2017; reviewed in Qi et al., 2023).
所含基因
20 个基因