MITF-M 依赖的参与代谢的基因调控
中文名称
通路描述
MITF 通过调节如 PPARGC1A (线粒体生物发生调节因子) 等基因的表达来调节细胞能量代谢。MITF 依赖的 PPARGC1A 表达使细胞向氧化磷酸化转变 (Haq et al, 2013; Vazquez et al, 2013)。MITF 还促进 SIRT1 (一种 NAD 依赖性去乙酰化酶) 的表达，SIRT1 作为细胞能量代谢的“调光器”，部分通过调节 p300 促进细胞增殖并抑制衰老 (Ohanna et al, 2014; Bouras et al, 2005)。
英文描述
Regulation of MITF-M dependent genes involved in metabolism MITF contributes to cellular energetics by regulating the expression of genes such as PPARGC1A, a regulator of mitochondrial biogenesis. MITF-dependent PPARGC1A expression shifts cells towards oxidative phosphorylation (Haq et al, 2013; Vazquez et al, 2013). MITF also promotes the expression of SIRT1, an NAD-dependent deacetylase that acts as a rheostat for cellular energetics. SIRT1 contributes to proliferation and inhibition of senescence in part through its regulation of p300 (Ohanna et al, 2014; Bouras et al, 2005).
所含基因
3 个基因