MITF-M 依赖的参与侵袭的基因调控
中文名称
通路描述
MITF 的靶点如 CEACAM1、GMPR 和 DIAPH1 通过影响细胞粘附并调节肌动蛋白细胞骨架来促进细胞迁移和侵袭。MITF 还调节参与上皮 - 间质转化 (EMT) 的基因表达，如 SNAI2 (Sanchez-Martin et al, 2002; Strub et al, 2011)。MITF 对侵袭性的变化在黑色素瘤背景下特别值得关注 (综述 Goding and Arnheiter, 2019; Cheli et al, 2010; White and Zon, 2008)。
英文描述
Regulation of MITF-M dependent genes involved in invasion Targets of MITF such as CEACAM1, GMPR and DIAPH1 contribute to cellular mobility and invasion by affecting cellular adhesion and regulating the actin cytoskeleton (Ullrich et al, 1995; Bianchi-Smiraglia et al, 2017; Carreira et al, 2006). MITF also regulates expression of genes involved in EMT such as SNAI2 (Sanchez-Martin et al, 2002; Strub et al, 2011). MITF-dependent changes in invasiveness are of particular interest in the context of melanoma (reviewed in Goding and Arnheiter, 2019; Cheli et al, 2010; White and Zon, 2008).
所含基因
4 个基因