PD-L1(CD274) 翻译的调节
中文名称
通路描述
PD-L1 (CD274) 蛋白从其 mRNA 合成到蛋白质的过程在各种生理和病理条件下受到微 RNA (miRNAs) 的严格调控，这些 miRNAs 结合到 PD-L1 mRNA 的 3'非翻译区 (3' UTR)，影响其稳定性和翻译效率 (Skafi 等人，2020; Wang 等人，2017)。例如，miR 34a 和 miR 200 直接靶向 PD-L1 mRNA，导致蛋白质合成减少，这在正常生理条件下控制自身免疫反应以及在癌症中免疫逃逸机制中很重要 (Danbaran 等人，2020; Kao 等人，2017; Grenda 等人，2017)。PD-L1 的翻译调节是癌症和其他疾病中研究的关键领域，特别是在 PD-L1 参与病理学的情况下 (Zhou 等人，2023; Ashrafizadeh 等人，2020)。
英文描述
Regulation of PD-L1(CD274) translation The synthesis of PD-L1 (CD274) protein from its mRNA under various physiological and pathological conditions is tightly regulated by microRNAs (miRNAs) that bind to the 3' untranslated region (3' UTR) of PD-L1 mRNA, influencing its stability and translation efficiency (Skafi et al., 2020, Wang et al., 2017). For example, miR 34a and miR 200 directly target PD L1 mRNA, leading to decreased protein synthesis, which is important in controlling autoimmune response in normal physiological conditions and immune escape mechanisms in cancer (Danbaran et al., 2020, Kao et al., 2017, Grenda et al., 2017). The translation regulation of PD-L1 is a critical area of research, particularly in the context of cancer and other diseases where PD-L1 is implicated in pathology (Zhou et al., 2023, Ashrafizadeh et al., 2020).
所含基因
9 个基因