雷因信号通路
中文名称
通路描述
雷因（RELN）是一种具有多种功能的细胞外信号糖蛋白，不仅控制发育中大脑神经元的定位，还调控成年大脑神经元的生长、成熟和突触活动。大脑中雷因表达异常与自闭症、精神分裂症、双相情感障碍和阿尔茨海默病等多种神经精神疾病有关。
英文描述
Assembly and Release of Dengue Virus Virions The newly synthesized Dengue virus (DENV) positive-sense RNA (+ssRNA) genomes are packaged into viral particles in the endoplasmic reticulum (ER), where they associate with the structural viral proteins C, prM, and E (reviewed in Rodenhuis Zybert et al. 2010). The immature viral particles are transported through the Golgi apparatus to exocytic vesicles, where prM is cleaved to form mature virions. In mature virions, E is organized as 90 head-to-tail orientated dimers of E:M heterodimers, which lie in sets of three, nearly parallel to each other and to the viral surface, forming a smooth ââherringboneââ configuration (E:M:M:E; reviewed in Rodenhuis-Zybert et al. 2010). Three E:M:M:E tetramers present in each icosahedral asymmetric unit exist in three chemically distinct environments and may therefore play a distinct role in different stages of the infection (reviewed in Rodenhuis-Zybert et al. 2010; Pierson & Diamond, 2012; Apte-Sengupta et al., 2014). The mature virions are released from the cell via exocytosis.
所含基因
9 个基因