Myristoylated proteins trafficking to the cilium
中文名称
通路描述
许多已证明具有脂酰基化的蛋白质以脂酰基和 UNC119B:ARL3:RP2 依赖的方式转运至纤毛。这些包括纤毛蛋白 Nephrocystin 3 (NPHP3) 和 Cystin 1 (CYS1) (Wright et al, 2011; 综述于 Schwarz et al, 2012)。脂酰基结合 ARL3 效应物 UNC119B 对于将脂酰基化货物转运至纤毛是必需的。在纤毛处，涉及 ARL3 和 GAP 蛋白 RP2 的 GTP 酶循环促进脂酰基化蛋白质释放到纤毛膜中，并促进 UNC119B 的回收和纤毛出口 (Wright et al, 2011; 综述于 Schwarz et al, 2012)。ARL3 还在纤毛中协调 IFT A 和 IFT B 复合物与 kinesin 马达的结合 (Li et al, 2010; 综述于 Li et al, 2012)。
英文描述
Dengue virus activates/modulates innate and adaptive immune responses Dengue virus nonstructural protein NS1 interacts with several parts of the complement system. In addition, nonstructural proteins, as well as prM and C, bind factors of the host's type I interferon antiviral response (reviewed in Ramirez & Urcuqui-Inchima, 2015; Cumberworth et al. 2017). The overall picture is known from many expression studies. For general reviews about DENV subversion of innate immunity see Kao et al., 2018; Tremblay et al., 2019; Carr et al., 2020; Kraivong et al., 2021; Pan et al., 2022. DENV also employs various strategies to evade the adaptive immune system, including antigenic variation and inhibition of antigen presentation (reviewed in Lee et al., 2022).
所含基因
35 个基因