经典 BAF 复合物的形成
中文名称
通路描述
哺乳动物经典 BRG1 相关因子 (BAF) 复合物是酿酒酵母 SWI/SNF 复合物的同旁异源物。cBAF 比相关的多溴化 BAF (pBAF) 复合物更小且更丰富。两个复合物共享的蛋白质（或蛋白质家族成员）构成了两个复合物的核心，包括 SMARCC 和 SMARCD 蛋白，催化亚基 SMARCA4 (BRG1) 或 SMARCA2 (BRM)，ACTB，ACTL6A/B 和 BCL7A/B/C (Wang, Cote 等人，1996; Wang, Xue 等人，1996; Mashtalir 等人，2018; Mashtalir 等人，2020; He 等人，2020; 综述于 Mittal 和 Robert2, 2020; Cenik 和 Shilatifard, 2021; Wang 和 Tang, 2023)。cBAF 复合物的区别性组分包括 ARID1A 或 ARID1B，以及 DPF1/2/3 和 SS18 或 SS18L1 (与 ncBAF 共享，如下所述) (综述于 Mittal 和 Roberts, 2020; Cenik 和 Shilatifard, 2021; Innis 和 Cabot; 2020; Wang 和 Tang, 2023)。哺乳动物 cBAF 复合物对于染色质重塑是必需的，并反对异染色质抑制 (Kadoch 等人，2017; Stanton 等人，2017; Wilson 等人，2010)。然而，与酵母不同，哺乳动物 cBAF 复合物能够支持基因激活和抑制 (Boyer 等人，2005; Ho 等人，2009)。
英文描述
Formation of the canonical BAF (cBAF) complex The mammalian canonical BRG1-associated factors (BAF) complex is the paralog of the budding yeast SWI/SNF complex. cBAF is smaller and more abundant than the related polybromo-associated BAF (pBAF) complex. Shared between the two complexes are proteins (or members of protein families) that make up the core of both complexes, including SMARCC and SMARCD proteins, the catalytic subunits SMARCA4 (BRG1) or SMARCA2 (BRM), ACTB, ACTL6A/B and BCL7A/B/C (Wang, Cote et al, 1996; Wang, Xue et al, 1996; Mashtalir et al, 2018; Mashtalir et al, 2020; He et al, 2020; reviewed in Mittal and Robert2, 2020; Cenik and Shilatifard, 2021; Wang and Tang, 2023). Distinguishing components of the cBAF complex include ARID1A or ARID1B, and DPF1/2/3, and SS18 or SS18L1 (shared with ncBAF, described below) (reviewed in Mittal and Roberts, 2020; Cenik and Shilatifard, 2021; Innis and Cabot; 2020; Wang and Tang, 2023).
Mammalian cBAF complexes are required for chromatin remodelling and oppose polycomb repression (Kadoch et al, 2017; Stanton et al, 2017; Wilson et al, 2010). Unlike in yeast, however, mammalian cBAF complexes are able to support both gene activation and repression (Boyer et al, 2005; Ho et al, 2009).
Mammalian cBAF complexes are required for chromatin remodelling and oppose polycomb repression (Kadoch et al, 2017; Stanton et al, 2017; Wilson et al, 2010). Unlike in yeast, however, mammalian cBAF complexes are able to support both gene activation and repression (Boyer et al, 2005; Ho et al, 2009).
所含基因
18 个基因