胚胎干细胞 BAF 复合物的形成
中文名称
通路描述
在啮齿动物和人类胚胎干细胞中已鉴定出一种独特的 BAF 复合物 (esBAF) (Ho, Jothi 等人，2009, Ho, Ronan 等人，2009; Zhang 等人，2014; 综述于 Kadoch 和 Crabtree, 2015; Cenik 和 Shilatifard, 2021; Innis 和 Cabot, 2020)。esBAF 的特征是包含 SMARCA4/BRG1 而不包含 SMARCA2/BRM 和 SMARCD1/BAF60A。在老鼠 esBAF 中仅使用 SMARCC1 (BAF155)，而人类 esBAF 似乎同时包含 SMARCC1 (BAF155) 和 SMARCC2 (BAF170) (Ho, Ronan 等人，2009; Ho, Jothi 等人，2009; Zhang 等人，2014; Wade 等人，2015)。esBAF 还包含亚基 BCL11A/B (Kadoch 等人，2013; 综述于 Kadoch 和 Crabtree, 2015; Innis 和 Cabot, 2020; Cenik 和 Shilatifard, 2021)。esBAF 与每个多能性因子共定位，且 esBAF 亚基的过表达在成纤维细胞中诱导多能性 (Ho, Ronan 等人，2009; Ho 等人，2011)。由于人类 esBAF 的组装尚未详细研究，该通路基于 cBAF, pBAF 和 ncBAF 的模块化组装 (Mashtalir 等人，2018; Mashtalir 等人，2020)。
英文描述
Formation of the embryonic stem cell BAF (esBAF) complex A distinct BAF complex has been identified in mouse and human embryonic stem cells (esBAF) (Ho, Jothi et al, 2009, Ho, Ronan et al, 2009; Zhang et al, 2014; reviewed in Kadoch and Crabtree, 2015; Cenik and Shilatifard, 2021; Innis and Cabot, 2020). esBAF is characterized by the presence of SMARCA4/BRG1 to the exclusion of SMARCA2/BRM and SMARCD1/BAF60A. Where mouse esBAF uses only SMARCC1 (BAF155), human esBAF appears to contain both SMARCC1 (BAF155) and SMARCC2 (BAF170) (Ho, Ronan et al, 2009; Ho, Jothi et al, 2009; Zhang et al, 2014; Wade et al, 2015). esBAF also contains subunits BCL11A/B (Kadoch et al, 2013; reviewed in Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021).
esBAF colocalizes with each of the pluripotency factors, and overexpression of esBAF subunits induces pluripotency in fibroblasts (Ho, Ronan et al, 2009; Ho et al, 2011).
As the assembly of human esBAF has not been examined in detail, this pathway is based on the modular assembly of cBAF, pBAF and ncBAF (Mashtalir et al, 2018; Mashtalir et al, 2020).
esBAF colocalizes with each of the pluripotency factors, and overexpression of esBAF subunits induces pluripotency in fibroblasts (Ho, Ronan et al, 2009; Ho et al, 2011).
As the assembly of human esBAF has not been examined in detail, this pathway is based on the modular assembly of cBAF, pBAF and ncBAF (Mashtalir et al, 2018; Mashtalir et al, 2020).
所含基因
19 个基因