Dectin-1 介导的非经典 NF-κB 信号通路
中文名称
通路描述
除了激活经典 NF-κB 亚基外，Dectin-1 激活的 SYK 通路诱导了非经典 NF-κB 通路，该通路通过依次激活 NF-κB 诱导激酶 (NIK) 和 IκB 激酶α (IKKa) 介导 RELB-p52 二聚体的核转位。非经典 NF-κB 通路激活速度较慢且持续时间更长。该通路以 NFKB2 (核因子 NF-κB) p100 亚基的翻译后加工为成熟 p52 亚基为特征，随后导致 p52:RELB (转录因子 RelB) 复合物核转位，诱导某些基因（如 C-C motif 趋化因子 17 (CCL17) 和 CCL22）的表达，并抑制其他基因（如 IL12B）的转录。
英文描述
Developmental Lineage of Multipotent Pancreatic Progenitor Cells Definitive endoderm forms during gastrulation and then undergoes patterning along anterior/posterior, dorsal/ventral, and median/lateral axes. Definitive endoderm cells produce, among other embryonal cell types, endoderm cells of dorsal and ventral foregut. The dorsal foregut endoderm cells, which transition through an intermediary duodeno-pancreatic endoderm cell state, and the ventral foregut endoderm cells, which possibly transition through a hepato-pancreatic or pancreato-biliary intermediary state, give rise to primary multipotent pancreatic progenitor cells (MPCs) that form dorsal and ventral pancreatic buds, respectively (Yu et al. 2019, reviewed in Jennings et al. 2015).
所含基因
17 个基因