磷酸戊糖途径
中文名称
通路描述
磷酸戊糖途径是葡萄糖周转的过程，产生 NADPH 作为还原当量以及戊糖作为核苷酸的重要组成部分。该途径有两个不同的阶段。一个是不可逆的氧化阶段，其中葡萄糖 -6-磷酸通过氧化脱羧转化为核酮 -5-磷酸，并生成 NADPH [MD:M00006]。另一个是可逆的非氧化阶段，其中磷酸化糖相互转化以生成木酮 -5-磷酸、核酮 -5-磷酸和核糖 -5-磷酸 [MD:M00007]。由核糖 -5-磷酸形成的磷酸核糖焦磷酸（PRPP）是一种活化化合物，用于组氨酸和嘌呤/嘧啶核苷酸的生物合成。该途径图还显示了 Entner-Doudoroff 途径，其中 6-磷酸葡萄糖酸脱水后裂解为丙酮酸和甘油醛 -3-磷酸 [MD:M00008]。
英文描述
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
所含基因
31 个基因