类固醇生物合成
中文名称
通路描述
类固醇生物合成通过甲羟戊酸途径将乙酰-CoA 转化为胆固醇（一种 27 碳固醇），胆固醇是所有类固醇激素（糖皮质激素、性激素）、维生素 D3 合成和胆汁酸的前体。关键调控酶是 HMG-CoA 还原酶，是 statin 药物的靶点。
英文描述
Steroid biosynthesis converts acetyl-CoA through the mevalonate pathway to cholesterol (a 27-carbon sterol), which serves as precursor for all steroid hormones (corticosteroids, sex steroids), vitamin D3 synthesis, and bile acids. Key regulatory enzyme is HMG-CoA reductase, targeted by statin drugs.
所含基因
20 个基因