初级胆汁酸生物合成
中文名称
通路描述
胆汁酸是脊椎动物从胆固醇衍生的类固醇羧酸。主要的胆汁酸胆酸和去氧胆酸在肝脏中合成，随后与甘氨酸或牛磺酸结合，通过胆汁分泌至肠道。胆固醇转化为胆酸和去氧胆酸的转化涉及四个步骤：1) 由 7α-羟基化启动固醇前体的合成，2) 对环结构的进一步修饰，3) 侧链氧化和缩短（裂解），4) 胆汁酸与甘氨酸或牛磺酸的结合。
英文描述
Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.
所含基因
17 个基因