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Tryptophan metabolism

KEGG ID: hsa00380

中文名称

色氨酸代谢

通路描述

色氨酸代谢分为合成血清素/褪黑素以产生神经递质,以及 kynurenine 途径(产生 NAD+ 前体的主要降解途径)。Kynurenine 活性失调会导致神经炎症疾病,包括抑郁症和阿尔茨海默病。
英文描述
Tryptophan metabolism bifurcates into serotonin/melatonin synthesis for neurotransmitter production, and the kynurenine pathway (the major catabolic route producing NAD+ precursors). Dysregulated kynurenine activity contributes to neuroinflammatory diseases including depression and Alzheimer's disease.

所含基因

42 个基因