磷酸酯和磷酸酯盐代谢
中文名称
通路描述
含碳磷键的天然产物，即所谓的 C-P 化合物，是磷酸酯和磷酸酯盐的衍生物，其中磷氢键上的氢被烷基取代。C-P 化合物在许多生物中发现，但仅存在于原生生物和细菌中，主要是放线菌。生物合成途径中常见的反应是磷酸烯醇式丙酮酸（PEP）到磷酸烯醇式丙酮酸磷酸酯（PnPy）的 C-P 键形成反应，由 PEP 磷酸酶催化。2-氨基乙基磷酸酯（AEP）是自然界中含量最多的 C-P 化合物。AEP 衍生物包括磷酸蛋白、磷酸糖蛋白和磷酸脂。其他已知的 C-P 化合物是用于医学（抗生素）和农业（除草剂）的生物活性物质，如 fosfomycin、FR-33289、rhizocticin 和 bialaphos。
英文描述
Natural products containing carbon-phosphorous bonds, so-called C-P compounds, are derivatives of phosphonate and phosphinate with substitution of alkyl group for hydrogen of phosphorus-hydrogen bonds. C-P compounds have been found in many organisms, but only protists and bacteria, mostly Actinobacteria, have biosynthetic capacity. A common reaction in the biosynthetic pathway is C-P bond forming reaction from phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalyzed by PEP phosphomutase. 2-Aminoethylphosphonate (AEP) is the most abundant C-P compound in the natural world. AEP derivatives include phosphonoprotein, phosphonoglycan, and phosphonolipid. Other known C-P compounds are bioactive substances used in medicine (antibiotics) and agriculture (herbicide) such as fosfomycin, FR-33289, rhizocticin, and bialaphos.
所含基因
6 个基因