花生四烯酸代谢
中文名称
通路描述
花生四烯酸代谢将膜磷脂中释放的 20 碳多不饱和脂肪酸通过 PLA2 转化为多样化的二十烷酸介质，通过环氧化酶（前列腺素和血栓烷）、脂氧合酶（白三烯）和细胞色素 P450 途径；它们是炎症、疼痛、血压和血小板功能的调节因子。
英文描述
Arachidonic acid metabolism converts this 20-carbon polyunsaturated fatty acid released from membrane phospholipids by PLA2 into diverse eicosanoid mediators via cyclooxygenase (prostaglandins and thromboxane), lipoxygenases (leukotrienes), and cytochrome P450 pathways; key regulators of inflammation, pain, blood pressure, and platelet function.
所含基因
63 个基因
AKR1C3
AKR1C8
ALOX12
ALOX12B
ALOX15
ALOX15B
ALOX5
ALOXE3
CBR1
CBR3
CYP2B6
CYP2C19
CYP2C8
CYP2C9
CYP2E1
CYP2J2
CYP2U1
CYP4F2
CYP4F3
CYP4F8
EPHX2
GGT1
GGT5
GPX4
HPGD
HPGDS
JMJD7-PLA2G4B
LOC102724197
LTA4H
LTC4S
PLA2G10
PLA2G12A
PLA2G12B
PLA2G1B
PLA2G2A
PLA2G2C
PLA2G2D
PLA2G2E
PLA2G2F
PLA2G3
PLA2G4A
PLA2G4B
PLA2G4C
PLA2G4D
PLA2G4E
PLA2G4F
PLA2G5
PLA2G6
PLAAT2
PLAAT3
PLB1
PRXL2B
PTGDS
PTGES
PTGES2
PTGES3
PTGIS
PTGR1
PTGR2
PTGR3
PTGS1
PTGS2
TBXAS1