细胞色素 P450 介导的外源物代谢
中文名称
通路描述
细胞色素 P450 酶（CYP 超家族）催化 I 相氧化反应，羟基化、环氧化或其他方式修饰外源物，包括药物、致癌物和环境化学品；CYP3A4、CYP2D6、CYP1A2 在肝脏中处理了大部分药物代谢。
英文描述
Xenobiotic metabolism by cytochrome P450 enzymes (CYP superfamily) catalyzes Phase I oxidation reactions that hydroxylate, epoxidize, or otherwise modify xenobiotics including drugs, carcinogens, and environmental chemicals; CYP3A4, CYP2D6, CYP1A2 handle the majority of drug metabolism in the liver.
所含基因
79 个基因
ADH1A
ADH1B
ADH1C
ADH4
ADH5
ADH6
ADH7
AKR1C1
AKR7A2
AKR7A3
AKR7L
ALDH3A1
ALDH3B1
ALDH3B2
CBR1
CBR3
CYP1A1
CYP1A2
CYP1B1
CYP2A13
CYP2A6
CYP2A7
CYP2B6
CYP2C9
CYP2D6
CYP2D7
CYP2E1
CYP2F1
CYP2S1
CYP3A4
CYP3A5
DHDH
EPHX1
GSTA1
GSTA2
GSTA3
GSTA4
GSTA5
GSTK1
GSTM1
GSTM2
GSTM3
GSTM4
GSTM5
GSTO1
GSTO2
GSTP1
GSTT1
GSTT2
GSTT2B
GSTT4
HPGDS
HSD11B1
HSD11B1L
LOC107987478
LOC107987479
MGST1
MGST2
MGST3
SULT2A1
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
UGT2A2
UGT2A3
UGT2B10
UGT2B11
UGT2B15
UGT2B17
UGT2B28
UGT2B4
UGT2B7