药物代谢 - 细胞色素 P450
中文名称
通路描述
细胞色素 P450 酶催化 I 相反应，包括对异生物体的羟基化和氧化；它们具有高度多态性，导致药物疗效和毒性在个体间存在差异。
英文描述
Drug metabolism — cytochrome P450 (same as hsa00980): CYP enzymes catalyze Phase I reactions including hydroxylation and epoxidation of xenobiotics; they are highly polymorphic, leading to inter-individual differences in drug efficacy and toxicity.
所含基因
73 个基因
ADH1A
ADH1B
ADH1C
ADH4
ADH5
ADH6
ADH7
ALDH3A1
ALDH3B1
ALDH3B2
AOX1
CYP1A2
CYP2A6
CYP2A7
CYP2B6
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2D7
CYP2E1
CYP3A4
CYP3A5
FMO1
FMO2
FMO3
FMO4
FMO5
GSTA1
GSTA2
GSTA3
GSTA4
GSTA5
GSTK1
GSTM1
GSTM2
GSTM3
GSTM4
GSTM5
GSTO1
GSTO2
GSTP1
GSTT1
GSTT2
GSTT2B
GSTT4
HPGDS
LOC107987478
LOC107987479
MAOA
MAOB
MGST1
MGST2
MGST3
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
UGT2A2
UGT2A3
UGT2B10
UGT2B11
UGT2B15
UGT2B17
UGT2B28
UGT2B4
UGT2B7