2-羧基酸代谢
中文名称
通路描述
2-羧基酸（也称为 2-酮酸和α-酮酸）是最基本的代谢物集合，包括丙酮酸（2-酮丙酸）、2-酮丁酸、草酰乙酸（2-酮琥珀酸）和α-酮戊二酸。此图说明了 2-羧基酸链延伸和修饰反应模块的架构。链延伸模块 RM001 使用乙酰-CoA 衍生的碳将链长度延长一个单位。链修饰模块 RM002（包括 RM032）和 RM033，以及还原胺化步骤（RC00006 或 RC00036），分别生成基本和支链氨基酸。修饰模块 RM030 用于植物次生代谢物 glucosinolates 的生物合成，将其转化为羟胺，然后添加硫葡萄糖基团。此外，2-氧代丁酸到 2-氧代苏巴吨的链延伸在甲烷化古菌中随后由辅酶 B 生物合成。
英文描述
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
所含基因
33 个基因