ATP 依赖性染色质重塑
中文名称
通路描述
ATP 依赖性染色质重塑利用 SWI/SNF、ISWI、CHD 和 INO80 家族复合物水解 ATP 产生的能量来重新定位或排出核小体，暴露 DNA 以供转录因子结合；SWI/SNF 组件的突变是人类癌症中最常见的改变之一。
英文描述
ATP-dependent chromatin remodeling uses energy from ATP hydrolysis via SWI/SNF, ISWI, CHD, and INO80 family complexes to reposition or eject nucleosomes exposing DNA for transcription factor binding; mutations in SWI/SNF components are among the most frequent alterations in human cancers.
所含基因
117 个基因
ACTB
ACTG1
ACTL6A
ACTL6B
ACTR5
ACTR6
ACTR8
ARID1A
ARID1B
ARID2
BACC1
BAZ1A
BAZ1B
BAZ2A
BAZ2B
BCL7A
BCL7B
BCL7C
BICRA
BICRAL
BPTF
BRD7
BRD8
BRD9
CDK2AP1
CDK2AP2
CECR2
CHD3
CHD4
CHRAC1
DMAP1
DPF1
DPF2
DPF3
EP400
EPC1
EPC2
GATAD2A
GATAD2B
H2AB1
H2AB2
H2AB3
H2AC1
H2AC11
H2AC12
H2AC13
H2AC14
H2AC15
H2AC16
H2AC17
H2AC18
H2AC19
H2AC20
H2AC21
H2AC25
H2AC4
H2AC6
H2AC7
H2AC8
H2AJ
H2AL3
H2AX
H2AZ1
H2AZ2
HDAC1
HDAC2
ING3
INO80
INO80B
INO80C
INO80D
INO80E
KAT5
MACROH2A1
MACROH2A2
MBD2
MBD3
MCRS1
MEAF6
MORF4L1
MORF4L2
MRGBP
MTA1
MTA2
MTA3
NFRKB
PBRM1
PHF10
PHF6
POLE3
RBBP4
RBBP7
RSF1
RUVBL1
RUVBL2
SMARCA1
SMARCA2
SMARCA4
SMARCA5
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SMARCD2
SMARCD3
SMARCE1
SRCAP
SS18
SS18L1
TFPT
TRRAP
UCHL5
VPS72
YEATS4
YY1
YY2
ZNHIT1