错配修复
中文名称
通路描述
DNA 错配修复（MMR）是一种高度保守的生物通路，在维持基因组稳定性方面起着关键作用。MMR 纠正 DNA 复制过程中产生的 DNA 错配，从而防止突变在分裂细胞中永久化。MMR 还抑制同源重组，最近的研究表明它还在 DNA 损伤信号传导中发挥作用。MMR 缺陷与全基因组不稳定性相关，易患某些类型的癌症，包括 HNPCC，并对某些化疗药物产生耐药性，且在哺乳动物系统中引起减数分裂异常和不育。
英文描述
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
所含基因
23 个基因