同源重组
中文名称
通路描述
同源重组（HR）对于准确修复 DNA 双链断裂（DSBs）以及潜在的致死性损伤至关重要。HR 发生在细胞周期的 S-G2 晚期，涉及 DNA 单链区域的产生、链入侵、形成 Holliday 结、以完整链为模板进行 DNA 合成、分支迁移和解决。研究表明，RecA/Rad51 家族蛋白质在其中发挥核心作用。乳腺癌易感蛋白 Brca2 和 RecQ 解旋酶 BLM（布罗姆综合征突变体）是肿瘤抑制因子，至少部分通过 HR 维持基因组完整性。
英文描述
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
所含基因
41 个基因