MET 激活 PTPN11

中文名称

MET 激活 PTPN11

通路描述

PTPN11 (SHP2) 通过 GAB1 被招募至激活的 MET 受体，并在 HGF 处理下发生磷酸化。虽然磷酸化位点和直接 MET 参与尚未被检查，但 PTPN11 对 HGF 处理的响应性磷酸化对于招募和激活 SPHK1 是必需的，这可能参与 HGF 诱导的细胞散射。同时，PTPN11 可在 MET 下游促进 MAPK3/1 (ERK1/2) 信号通路，也可在未鉴定的酪氨酸残基上脱磷酸化 MET。

英文描述

Efferocytosis: engulfment of dying apoptotic cells by macrophages recognizing "eat-me" signals like phosphatidylserine exposure on apoptotic surfaces; prevents inflammatory tissue damage and is important in wound healing, immune tolerance, and cancer progression.

所含基因

157 个基因

ABCA1 ADAM10 ADAM17 ADAM9 ADGRB1 AGER ALOX15 ALOX5 ANO3 ANO4 ANO5 ANO6 ANO7 ANO9 ARG1 ARG2 ARNT ATP11A ATP11B ATP11C ATP2A1 ATP2A2 ATP2A3 ATP8A1 ATP8A2 AXL BCAR1 BSG C1QA C1QB C1QC CALR CAMK2A CAMK2B CAMK2D CAMK2G CASP1 CASP3 CASP7 CD24 CD36 CD47 CDC50A CDC50B CEBPB CH25H CPT1A CPT1B CPT1C CREB1 CRK CRKL CX3CL1 CX3CR1 DNMT3A DOCK1 DUSP16 DUSP2 DUSP4 DUSP5 DUSP7 DUSP8 ELMO1 EPO EPOR GAS6 GPR132 GULP1 HAVCR1 HAVCR2 HIF1A IL10 ITGAV ITGB3 ITGB5 JAK2 LIPA LRP1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MEGF10 MEGF11 MERTK MFGE8 NFATC1 NFATC2 NFATC3 NFATC4 NR1H2 NR1H3 ODC1 P2RY12 P2RY2 P2RY6 PANX1 PBX1 PECAM1 PLA2G15 PLA2G6 PPARD PPARG PROS1 PTGER2 PTGER4 PTGS2 PTK2 PTPN11 PTPN6 RAB14 RAB17 RAB5A RAB5B RAB5C RAB7A RAB7B RAC1 RXRA S1PR1 SCARF1 SGK1 SIGLEC10 SIRPA SIRPB1 SIRPG SIRT1 SLC16A1 SLC2A1 SLC66A1 SPHK1 SPHK2 STAB1 STAB2 TGFB1 TGFBRAP1 THBS1 TIMD4 TYRO3 UQCRFS1 VPS11 VPS16 VPS18 VPS33A VPS39 VPS41 VPS8 XKR4 XKR6 XKR7 XKR8 XKR9