NTF3 激活 NTRK2 (TRKB) 信号通路
中文名称
通路描述
神经生长因子受体酪氨酸激酶 NTRK2 (TRKB) 是神经生长因子 -3 (NTF3, 也称为 NT-3) 的低亲和力受体。NTF3 主要作为 NTRK3 (TRKC) 受体的配体发挥作用。与 BDNF 和 NTF3 结合 NTRK2 二聚化以及受体胞质尾部酪氨酸残基上的二聚体磷酸化有关，但 NTRK2 对 NTF3 的激活效率较低，且下游信号传导尚未被研究。
英文描述
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
所含基因
42 个基因