角化膜形成

中文名称

角化膜形成

通路描述

角化膜形成通过交联蛋白质（如 involucrin, loricrin）形成角质层保护性层，产生防止水分流失、病原体及化学品的屏障；需要角质层细胞中高浓度的钙离子产生屏障。

英文描述

Cornified envelope formation creates the protective keratin layer of epidermis by cross-linking proteins (involucrin, loricrin) into a tough insoluble sheet; requires high calcium concentration in stratum granulosum cells to produce the barrier against water loss, pathogens, and chemicals.

所含基因

217 个基因

ABCA12 ABHD5 ALOX12B ALOXE3 ASPRV1 BLMH CAPN1 CASP14 CDSN CERS3 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN24 CLDN25 CLDN3 CLDN34 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 COL17A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL7A1 CYP4F22 DSC1 DSG1 DSG2 DSG3 DSG4 DSP DST ELOVL1 ELOVL4 EPHX2 EPHX3 EVPL FLG FLG2 FURIN GBA1 GBA2 HAL HRNR ITGA6 ITGB4 IVL JUP KAZN KDSR KRT1 KRT10 KRT12 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT2 KRT20 KRT23 KRT24 KRT25 KRT26 KRT27 KRT28 KRT3 KRT31 KRT32 KRT33A KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT4 KRT40 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT84 KRT85 KRT86 KRT9 LAMA3 LAMA5 LAMB3 LAMC2 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LCE7A LOC100653049 LORICRIN OCLN PADI1 PADI2 PADI3 PADI6 PCSK6 PKP1 PKP2 PKP3 PLEC PNPLA1 PPL PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R2D PPP2R3A PPP2R3B PPP2R3C PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRSS8 S100A1 S100A10 S100A11 S100A12 S100A13 S100A14 S100A16 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7 S100A7A S100A8 S100A9 SDR9C7 SLC27A1 SLC27A4 SPRR1A SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G SPRR3 SPRR4 SPRR5 SPTLC1 SPTLC2 SPTLC3 ST14 TCHH TCHHL1 TGM1 TGM3 TGM5 TJP1 TMEM79 UGCG