Hippo 信号通路 - 多种物种
中文名称
通路描述
Hippo 信号通路控制真核生物细胞增殖、生存和形态发生等多样方面。这些网络的组织在数亿年的进化中高度保守，在动物和真菌中描述了相关形式。在果蝇和哺乳动物中，Hippo/MST 与 Mats/Mob1 和 Salvador/WW45 合作激活 Warts/LATS，后者负性调节 Yorkie/YAP。Yorkie/YAP 与 Scalloped/TEAD 相互作用，促进基因转录并通过细胞增殖与凋亡之间的平衡控制器官大小。在秀丽隐杆线虫中，WTS-1 YAP-1 EGL-44 轴得到保守，调节热耐受和健康寿命。在酿酒酵母中，LATS 相关的 Dbf2 或 Dbf20 激酶与 Mob1 形成复合物控制有丝分裂退出和胞质分裂，而 Hippo/MST 家族的激酶 STE-20 调节 Tec1，这是拟酵母 TEAD 的同源物。
英文描述
Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.
所含基因
29 个基因