肾素 - 血管紧张素系统
中文名称
通路描述
肾素 - 血管紧张素系统 (RAS) 是一种具有内分泌特性的肽性系统，用于调节血压和水电解质平衡。在经典 RAS 中，酶肾素将其底物血管紧张素原 (Agt) 切割形成十肽血管紧张素 I，后者随后被血管紧张素转化酶 (ACE) 切割产生血管紧张素 II (Ang II)，该系统的关键调节因子。Ang II 激活其 AT1 受体 (AT1R)，这是主要介导 Ang II 在肾脏中已知作用的主受体，包括血管收缩、肾钠 (Na+) 重吸收和醛固酮分泌，从而增加血压并促进高血压的发展。除了 (ACE)/Ang II/AT1R 和 AT2R 轴外，RAS 中的其他信号通路，如 ACE2/血管紧张素-(1-7)/Mas 和 Ang IV/IRAP，以及其他具有生理意义的 RAS 活性肽 Ang III、Ang A 和 alamandine，现在已被广泛认可。
英文描述
The renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the enzyme renin cleaves its substrate angiotensinogen (Agt) forming the decapeptide angiotensin I that is in turn cleaved by angiotensin-converting enzyme (ACE) to produce the angiotensin II (Ang II), a key player of this system. Ang II activates its AT1 receptor (AT1R), the principal receptor that mediates the majority of the known actions of Ang II in the kidney, including vasoconstriction, renal sodium (Na+) reabsorption, and aldosterone secretion, increasing blood pressure and contributing to the development of hypertension. In addition to (ACE)/Ang II/AT1R and AT2R axis, other signaling pathways in the RAS, such as ACE2/angiotensin-(1-7)/Mas and Ang IV/IRAP, and other active peptide of the RAS, with physiological relevance as Ang III, Ang A and alamandine, are now widely recognized.
所含基因
23 个基因