II型Na+/Pi共转运体
中文名称
通路描述
II型Na+/Pi共转运体属于SLC34家族，包含三个成员：NaPi-IIa（SLC34A1）、NaPi-IIb（SLC34A2）和NaPi-IIc（SLC34A3）（Murer H等，2004）。它们主要在肾脏和小肠表达，位于上皮细胞的顶端部位，尽管身体其他部位也有少量表达。NaPi-IIa和b共转运体以三价磷酸根离子（HPO4[2-]）与三个Na+离子进行电致性转运，而NaPi-IIc共转运体以二价磷酸根离子与两个Na+离子进行电中性转运。
英文描述
Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.
所含基因
47 个基因