核蛋白成熟
中文名称
通路描述
该 COVID-19 通路是通过结合 SARS-CoV-1 数据的计算推断和手动校订创建的，具体描述见整体 SARS-CoV-2 感染通路摘要。核蛋白是感染期间表达的最丰富的病毒蛋白，存在于宿主细胞胞质、细胞核和质膜中。经磷酸化和苏糖基化后，它形成二聚体或四聚体，并被转运至高尔基体（病毒出芽位点）。
英文描述
One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "new HCO3(-)" for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the "new HCO3(-)" by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-) , which is "new HCO3(-) ," is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids.
所含基因
23 个基因