非洲锥虫病
中文名称
通路描述
Trypanosoma brucei是引起非洲锥虫病（睡眠病）的寄生虫，通过钉螺传播。该寄生虫能够穿过血脑屏障，并通过诱导TNF-α、IFN-γ和IL-1等细胞因子引起神经系统损伤。这些细胞因子和其他代谢产物如一氧化氮和嗜神经素前列腺素D2扰乱非洲锥虫病患者的昼夜节律。
英文描述
Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN gamma, and IL1. These cytokines and other metabolites such as nitric oxide and somnogenic prostaglandin D2 disturb circadian rhythms in patients with African trypanosomiasis.
所含基因
37 个基因