← 返回搜索

Pathways in cancer

KEGG ID: hsa05200

中文名称

癌症通路

通路描述

癌症通路整合了多种致癌信号通路，包括 RTK/RAS/MAPK（增殖）、PI3K/AKT/mTOR（生存/生长）、p53（肿瘤抑制调节细胞周期/DNA 修复）、Wnt/beta-catenin、NOTCH、JAK/STAT、TGF-beta 和 Hippo 通路——这些是人类肿瘤中最常突变的基因。
英文描述
Pathways in cancer: integrates multiple oncogenic signaling pathways including RTK/RAS/MAPK (proliferation), PI3K/AKT/mTOR (survival/growth), p53 (tumor suppressor regulating cell cycle/DNA repair), Wnt/beta-catenin, NOTCH, JAK/STAT, TGF-beta, and Hippo pathways — the most frequently mutated genes in human tumors.

所含基因

533 个基因
ABL1 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AGT AGTR1 AKT1 AKT2 AKT3 ALK APAF1 APC APC2 APPL1 AR ARAF ARHGEF1 ARHGEF11 ARHGEF12 ARNT ARNT2 AXIN1 AXIN2 BAD BAK1 BAX BBC3 BCL2 BCL2L1 BCL2L11 BCR BDKRB1 BDKRB2 BID BIRC2 BIRC3 BIRC5 BIRC7 BMP2 BMP4 BRAF BRCA2 CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK2A CAMK2B CAMK2D CAMK2G CASP3 CASP7 CASP8 CASP9 CBL CCDC6 CCNA1 CCNA2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CDC42 CDH1 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CEBPA CHUK CKS1B CKS2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CREBBP CRK CRKL CSF1R CSF2RA CSF2RB CSF3R CTBP1 CTBP2 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CUL1 CUL2 CXCL12 CXCL8 CXCR4 CYCS DAPK1 DAPK2 DAPK3 DCC DDB2 DLL1 DLL3 DLL4 DVL1 DVL2 DVL3 E2F1 E2F2 E2F3 EDN1 EDNRA EDNRB EGF EGFR EGLN1 EGLN2 EGLN3 ELK1 ELOB ELOC EML4 EP300 EPAS1 EPO EPOR ERBB2 ESR1 ESR2 ETS1 F2 F2R F2RL3 FADD FAS FASLG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FH FLT3 FLT3LG FLT4 FN1 FOS FOXO1 FRAT1 FRAT2 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GADD45A GADD45B GADD45G GLI1 GLI2 GLI3 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GSK3B GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTT4 HDAC1 HDAC2 HES1 HES5 HEY1 HEY2 HEYL HGF HHIP HIF1A HMOX1 HRAS HSP90AA1 HSP90AB1 HSP90B1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNG IFNGR1 IFNGR2 IGF1 IGF1R IGF2 IKBKB IKBKG IL12A IL12B IL12RB1 IL12RB2 IL13 IL13RA1 IL15 IL15RA IL2 IL23A IL23R IL2RA IL2RB IL2RG IL3 IL3RA IL4 IL4R IL5 IL5RA IL6 IL6R IL6ST IL7 IL7R ITGA2 ITGA2B ITGA3 ITGA6 ITGAV ITGB1 JAG1 JAG2 JAK1 JAK2 JAK3 JUN JUP KEAP1 KIF7 KIT KITLG KLK3 KNG1 KRAS LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 LEF1 LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LRP5 LRP6 MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MAX MDM2 MECOM MET MGST1 MGST2 MGST3 MITF MLH1 MMP1 MMP2 MMP9 MSH2 MSH3 MSH6 MTOR MYC NCOA1 NCOA3 NCOA4 NFE2L2 NFKB1 NFKB2 NFKBIA NKX3-1 NOS2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NQO1 NRAS NTRK1 P3R3URF-PIK3R3 PAX8 PDGFA PDGFB PDGFRA PDGFRB PGF PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIM1 PIM2 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PLD1 PLD2 PLEKHG5 PMAIP1 PML POLK PPARD PPARG PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PTCH1 PTCH2 PTEN PTGER1 PTGER2 PTGER3 PTGER4 PTGS2 PTK2 RAC1 RAC2 RAC3 RAD51 RAF1 RALA RALB RALBP1 RALGDS RARA RARB RASGRP1 RASGRP2 RASGRP3 RASGRP4 RASSF1 RASSF5 RB1 RBX1 RELA RET RHOA ROCK1 ROCK2 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX1T1 RXRA RXRB RXRG SHH SKP1 SKP2 SLC2A1 SMAD2 SMAD3 SMAD4 SMO SOS1 SOS2 SP1 SPI1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 STK4 SUFU TCF7 TCF7L1 TCF7L2 TERC TERT TFG TGFA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TP53 TPM3 TPR TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TXNRD1 TXNRD2 TXNRD3 VEGFA VEGFB VEGFC VEGFD VHL WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XIAP ZBTB16 ZBTB17