甲状腺癌
中文名称
通路描述
甲状腺癌是最常见的内分泌恶性肿瘤，每年占内分泌癌症相关死亡病例的绝大多数。超过 95% 的甲状腺癌瘤细胞来源于滤泡细胞。其行为从生长缓慢、分化良好的乳头状和滤泡状癌（PTC 和 FTC，分别）到极度侵袭性的未分化癌（UC）不等。RET 和 TRK 的体细胞重排几乎仅见于乳头状癌，并可能出现在早期阶段。FTC 最独特的分子特征包括异倍体的高度和 RAS 突变的高发生率以及 PAX8-PPARγ重排。p53 似乎在整个甲状腺癌的分化过程中起关键作用。
英文描述
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
所含基因
37 个基因