类风湿关节炎

中文名称

类风湿关节炎

通路描述

类风湿关节炎（RA）是一种慢性自身免疫性关节病，持续炎症导致骨重塑异常，进而引起进行性骨破坏。在 RA 中，免疫系统异常激活导致促炎细胞因子和趋化因子水平升高，可促进滑膜血管生成和白细胞浸润。滑膜形成增生性炎性肉芽肿，含有浸润的巨噬细胞样和成纤维细胞样滑膜细胞，并通过分泌蛋白酶诱导成骨细胞分化，进而侵袭关节。

英文描述

Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation.

所含基因

95 个基因

ACP5 ANGPT1 ATP6AP1 ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H CCL2 CCL20 CCL3 CCL3L1 CCL3L3 CCL5 CD28 CD80 CD86 CSF1 CSF2 CTLA4 CTSK CTSL CXCL1 CXCL12 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 FLT1 FOS HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ICAM1 IFNG IL11 IL15 IL17A IL18 IL1A IL1B IL23A IL6 ITGAL ITGB2 JUN LOC101927180 LOC102723407 LTB MMP1 MMP3 PTH TCIRG1 TEK TGFB1 TGFB2 TGFB3 TLR2 TLR4 TNF TNFRSF11A TNFSF11 TNFSF13 TNFSF13B VEGFA